1. Vegan Peanut Butter Cup Cookies (Gluten-Free!)
  2. Kid-approved vegan eats
  3. Fudgy Avocado Walnut Brownies
  4. Healthy Vegetarian Meal Plan: Week of 12-07-2019
  5. Amazing Vegan Ginger Molasses Cookies
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  53. 33 Mouthwatering Healthy Vegetarian Recipes for Dinner Tonight
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  55. The Best Apple Cider Vinegar Salad Dressing
  56. VOTE TODAY!
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  58. Twilight Time: Reading With Kids
  59. Keep your cool
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  80. Do Memory Problems Always Mean Alzheimers Disease?
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  82. Study Shows that Disrupted Gut Bacteria May Contribute to the Spread of Breast Cancer
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  113. Scientists revive cellular activity in brain of dead pigs: report – Fox News
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Saturday, December 14, 2019
  1. Vegan Peanut Butter Cup Cookies (Gluten-Free!)
  2. Kid-approved vegan eats
  3. Fudgy Avocado Walnut Brownies
  4. Healthy Vegetarian Meal Plan: Week of 12-07-2019
  5. Amazing Vegan Ginger Molasses Cookies
  6. 2019 Holiday Gift Guide For Her
  7. Herbal Inclusions for Dishes and Drinks
  8. 4 Diabetes Game Changers
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  10. Instant Pot Mashed Potatoes with Garlic and Cream Cheese
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  12. Wedding Planning: The Ring, Our Vendors, and More!
  13. Instant Pot Vegan Cream of Mushroom and Wild Rice Soup
  14. Healthy Vegetarian Meal Plan: Week of 11-16-2019
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  16. Healthy Vegetarian Meal Plan: Week of 11-02-2019
  17. Roasted Potato, Mushroom, and Lentil Kale Salad
  18. Healthy Vegetarian Meal Plan: Week of 11-09-2019
  19. Healthy Vegetarian Meal Plan
  20. Healthy Vegetarian Meal Plan
  21. What I Wednesday: FNCE in Philly!
  22. Potato, Mushroom, and Lentil Kale Salad
  23. Healthy Vegetarian Meal Plan
  24. Unearthing Evidence-Based Integrative Remedies to Stress
  25. Scribble Anxiety Away
  26. Best Hostess Gift Ever
  27. What I Ate Wednesday: Fiancé Edition!
  28. Pumpkin Walnut Burgers with Chipotle Yogurt Sauce
  29. Favorite Fluffy Whole Wheat Pancakes
  30. Healthy Vegetarian Meal Plan
  31. Vegan Chili Cornbread Casserole
  32. Healthy Vegetarian Meal Plan
  33. Orca Conservation
  34. Fall’s Functional Foods
  35. Healthy Vegetarian Meal Plan
  36. Healthy Pumpkin Cheesecake Dip
  37. Simple Swaps for Your Zero Waste Journey
  38. Lessons on Food and Farming in Monterey, California
  39. Healthy Vegetarian Meal Plan
  40. Quick and Easy-One Pan Veggie Red Curry
  41. Healthy Vegetarian Meal Plan: Week of 09-21-2019
  42. Here’s How to Live a more Colourful Life
  43. Cooking with CBD
  44. Eco-friendly Food Storage
  45. Bento Box Recipes
  46. How to Make Sushi Sandwich
  47. Healthy Vegan Buffalo Cauliflower Dip
  48. Healthy Vegetarian Meal Plan: Week of 09-14-2019
  49. 5 lunchbox ideas
  50. 17 Free and Easy Ways to Be a Self-Care Expert
  51. Fluffy Vegan Pumpkin Muffins
  52. Healthy Vegetarian Meal Plan: Week of 09-07-2019
  53. 33 Mouthwatering Healthy Vegetarian Recipes for Dinner Tonight
  54. What I Ate Wednesday
  55. The Best Apple Cider Vinegar Salad Dressing
  56. VOTE TODAY!
  57. Veggie Stir Fry with Peanut Sauce
  58. Twilight Time: Reading With Kids
  59. Keep your cool
  60. Tart Cherry Crumble Pie
  61. Healthy Vegetarian Meal Plan
  62. Healthy Vegetarian Meal Plan
  63. Your brain on… air pollution?
  64. Brain Boosters
  65. MCT oil Coconut’s healthful gift
  66. Hot right now
  67. Cupcakes for breakfast?
  68. Vegan Chocolate Zucchini Muffins
  69. What is CBD? A Guide to Health Benefits, Usage, and More!
  70. Healthy Vegetarian Meal Plan
  71. Hummus Toast – 4 Ways!
  72. What I Ate Wednesday
  73. Fluffy Vegan Blueberry Banana Muffins
  74. Advances in Colorectal Cancer Research
  75. Advances in Breast Cancer Research
  76. Cleft Palate With Cleft Lip
  77. What is CPR?
  78. What Is Dementia? Symptoms, Types, and Diagnosis
  79. Cushing Syndrome (For Parents)
  80. Do Memory Problems Always Mean Alzheimers Disease?
  81. Manganese
  82. Study Shows that Disrupted Gut Bacteria May Contribute to the Spread of Breast Cancer
  83. She Faced Breast Cancer At 16 With Little Help From Doctors. Now She’s Speaking Out On Behalf Of Black Women
  84. What Do We Know About Healthy Aging?
  85. Participating in the Arts Creates Paths to Healthy Aging
  86. Setting Goals to be More Active Slows Memory Decline in Older African Americans
  87. Study Shows Music Eases Pain and Other Symptoms for Patients Undergoing Breast Cancer Treatment
  88. 49-Year-Old Breast Cancer Patient Grateful She Didn’t Wait Until 50 for a Mammogram
  89. Teen’s Innovative “SMART Armour” Protects Breast Cancer Patients from Radiation
  90. New Drug Improves 3-Year Survival by 50% for Young Women with Stage IV Breast Cancer
  91. Young Mother’s Life Tragically Taken by Breast Cancer After She Refused Traditional Treatments
  92. NIH Study Tracks Exercise with Mobile Apps to Improve Heart Health
  93. Lion With Skin Cancer Has Received Radiation Therapy In Hospital
  94. 3rd Grader Writes Note for Teacher Battling Breast Cancer to Read Right Before Treatment
  95. Skin Care
  96. Have Back Pain? These Are the Basic Spinal Structures You Need to Know
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  99. Julia Louis-Dreyfus Talks About The Side Effects of Chemotherapy
  100. Teacher on Leave for Breast Cancer Treatment Forced to Pay for Her Own Substitute
  101. 27-Year-Old Thought She Was Injured Falling Off A Horse, But Then She Learned She Had Breast Cancer
  102. Should Surgery And Radiation Be The Standard Treatment For DCIS? The COMET Study Is Finding Out
  103. Judge Rules That 3-Year-Old Child With Leukemia Must Get Chemo Against Parents’ Wishes
  104. This Charcoal Powder Drastically Whitens Teeth Without Any Chemicals
  105. These Black Cherry-Flavored Shots Help Accelerate Weight Loss
  106. Olivia Newton-John Talks About How She Stays Positive Amid Cancer Battle
  107. This Army Captain Mom Was Diagnosed with Breast Cancer When She Was Just 8 Weeks Pregnant
  108. High-Deductible Health Plans Linked to Delayed Diagnosis and Treatment of Breast Cancer
  109. Antibiotic shortages are putting Aboriginal kids at risk – The Conversation AU
  110. Cuddle beds bringing some physical comfort to end-of-life patients – ABC News
  111. People who skip breakfast are five times more likely to die after a heart attack – Daily Mail
  112. Yale researchers revive cells in dead pig brains – Yale Daily News
  113. Scientists revive cellular activity in brain of dead pigs: report – Fox News
  114. High-Deductible Health Policies Linked To Delayed Diagnosis And Treatment – NPR
  115. After Breast Cancer Diagnosis, Technology Professor Teaches Computers to Read Mammograms
  116. Fact or Fiction: What to Know About Smoking Cessation and Medications
  117. If Soap and Water Are Not Available, Hand Sanitizers May Be a Good Alternative
  118. Autism: Beware of Potentially Dangerous Therapies and Products
  119. One side of your brain might be giving you nightmares – Cosmos
  120. What Personality Tests Tell Us About Ourselves – NPR
  121. Having a resting heart rate of 75 beats per minute DOUBLES your risk of an early death – Daily Mail
  122. Wear protective goggles to play badminton
  123. Herbal drug kratom linked to almost 100 overdose deaths, CDC says – USA TODAY
  124. Ability to lift weights quickly can mean a longer life – EurekAlert
  125. Climate change is making allergy season worse – CNN
  126. 11 Unexpected Ways You Can Relieve Headaches – HuffPost
  127. New Jersey preschoolers have highest autism rates in the nation, researchers say
  128. Auburn gymnast who suffered severe injuries: My pain is not your entertainment
  129. A four-day work week could improve our health and cut carbon emissions
  130. Promising treatment for chronic fatigue syndrome fails large trial

YaleNew

In a stunning scientific breakthrough, Yale School of Medicine researchers restored brain activity in pigs that had died hours before. The finding could revolutionize the neuroscience field and how scientists conceive the boundaries between life and death.

By circulating a cocktail of cell-rejuvenating compounds throughout the pigs’ brains, the researchers prevented tissue decomposition and restored some cell function. If replicated, their technique could be used as a model for drug testing and has implications for how scientists understand brain plasticity after traumatic events such as strokes. 

But the researchers stressed that they did not restore consciousness to the brains. Although the group observed activity in individual cells, the brains lacked widespread, coordinated activity — a requirement for consciousness.

“We wanted to investigate what happens in the brain following global injury … and whether we could restore certain cellular and molecular functions in the whole, intact brain four hours after death,” co-first author Stefano Daniele GRD ’21 told the News. “We were successfully able to do so.” 

Daniele and co-first author Zvonimir Vrselja, research scientist in neuroscience, headed the study under the supervision of School of Medicine neuroscience professor Nenad Sestan.

It took Vrselja and Daniele several years of trial-and-error to refine their research protocol. In the end, each successful trial required a 10-hour sprint.

“We have an entire dance that we do,” Daniele said.

Typically, scientists will purchase test animals from speciality research companies. But Vrselja and Daniele took a different approach: Each iteration of the experiment began at a local food processing plant where the duo would wait for new specimen to become available.

“We did not want to kill any animals for this research,” Daniele explained. “ So we just simply made use of tissue that was going to be discarded.”

After securing the tissue, the two rushed back to the School of Medicine and removed the pig’s brain from its skull within four hours.

Vreslja and Daniele designed a system to pump and circulate their solution throughout the brain. For six hours, the contraption acted like an artificial circulatory system — pushing solution around the brain while simultaneously removing waste from the tissue.

“A lot of these components are readily available and no one really thought to put them together in a particular manner that could result in this type of study,” Daniele said.

Miraculously, following the treatment, the team was able to repeatedly show that cells in the brain could respond to stimuli. Drug treatment expanded the brain’s blood vessels. And individual neurons gave bursts of electrical activity.

By all accounts, a brain deprived of oxygen and other nutrients for four hours is considered dead. But the activity described in the study shows that brain cells are more robust and are able to survive longer than previously thought.

Still, for now, clinical definitions of brain death are intact.

“I don’t see anything in this report that should undermine confidence in brain death as a criterion of death,” Winston Chiong, a neurologist at the University of California at San Francisco told The Atlantic.

In 2016, when the team grew concerned that their experiment would cause neurons across the brain to fire together — the marker for consciousness —  they recruited Yale Interdisciplinary Center for Bioethics Director Stephen Latham, who became a co-author of the study.

In all studies involving human or animal subjects, federal law mandates that scientists must consult their institution’s ethics committees before starting research.Though the present study passed the bar, future studies may enter an ethical gray area.

“A disembodied brain that’s obtained from a pig that’s already dead is not an animal and it’s not a human subject,” Latham explained. “Nobody has jurisdiction to ask questions like ‘is this brain suffering? Can it suffer if it’s sitting alone in a vat unconnected to a body? Even if we see EEG [signal], does that indicate consciousness? Does it indicate pained consciousness in any way?’”

Following the landmark study’s publication, Sestan, the senior author, is calling for independent groups to replicate the findings.

Others in the medical community agree. Yale New Haven Hospital Chief of Neurology David Hafler, who was not involved in the study, told the News that the work needs replicating as the “natural process of science” drums onward.

“Until the work is replicated independently by another laboratory,” he said, “in my mind it doesn’t exist.”

Still, Hafler said that the results of the Yale study are “one of the most remarkable findings I’ve seen in my career.”

“I really congratulate them for just a game-changing paper,” Hafler told the News. “They should be proud to be from Yale.”

As of Wednesday night, Nature reported that 132 news outlets have picked up the study.

Marisa Peryer | marisa.peryer@yale.edu

Matt Kristoffersen | matthew.kristoffersen@yale.edu

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