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  3. Can neurogastronomy save the world?
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  16. Mediterranean Vegetable Pasta with Chickpeas
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  22. Sweet Potato Rounds with Goat Cheese, Roasted Grapes, and Pecans
  23. Healthy Vegetarian Meal Plan: Week of 12-14-2019
  24. Vegan Peanut Butter Cup Cookies (Gluten-Free!)
  25. Kid-approved vegan eats
  26. Fudgy Avocado Walnut Brownies
  27. Healthy Vegetarian Meal Plan: Week of 12-07-2019
  28. Amazing Vegan Ginger Molasses Cookies
  29. 2019 Holiday Gift Guide For Her
  30. Herbal Inclusions for Dishes and Drinks
  31. 4 Diabetes Game Changers
  32. Healthy Vegetarian Meal Plan: Week of 11-30-2019
  33. Instant Pot Mashed Potatoes with Garlic and Cream Cheese
  34. Healthy Vegetarian Meal Plan: Week of 11-23-2019
  35. Wedding Planning: The Ring, Our Vendors, and More!
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  40. Roasted Potato, Mushroom, and Lentil Kale Salad
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  42. Healthy Vegetarian Meal Plan
  43. Healthy Vegetarian Meal Plan
  44. What I Wednesday: FNCE in Philly!
  45. Potato, Mushroom, and Lentil Kale Salad
  46. Healthy Vegetarian Meal Plan
  47. Unearthing Evidence-Based Integrative Remedies to Stress
  48. Scribble Anxiety Away
  49. Best Hostess Gift Ever
  50. What I Ate Wednesday: Fiancé Edition!
  51. Pumpkin Walnut Burgers with Chipotle Yogurt Sauce
  52. Favorite Fluffy Whole Wheat Pancakes
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  54. Vegan Chili Cornbread Casserole
  55. Healthy Vegetarian Meal Plan
  56. Orca Conservation
  57. Fall’s Functional Foods
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  59. Healthy Pumpkin Cheesecake Dip
  60. Simple Swaps for Your Zero Waste Journey
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  68. Bento Box Recipes
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  71. Healthy Vegetarian Meal Plan: Week of 09-14-2019
  72. 5 lunchbox ideas
  73. 17 Free and Easy Ways to Be a Self-Care Expert
  74. Fluffy Vegan Pumpkin Muffins
  75. Healthy Vegetarian Meal Plan: Week of 09-07-2019
  76. 33 Mouthwatering Healthy Vegetarian Recipes for Dinner Tonight
  77. What I Ate Wednesday
  78. The Best Apple Cider Vinegar Salad Dressing
  79. VOTE TODAY!
  80. Veggie Stir Fry with Peanut Sauce
  81. Twilight Time: Reading With Kids
  82. Keep your cool
  83. Tart Cherry Crumble Pie
  84. Healthy Vegetarian Meal Plan
  85. Healthy Vegetarian Meal Plan
  86. Your brain on… air pollution?
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  94. Hummus Toast – 4 Ways!
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  98. Advances in Breast Cancer Research
  99. Cleft Palate With Cleft Lip
  100. What is CPR?
  101. What Is Dementia? Symptoms, Types, and Diagnosis
  102. Cushing Syndrome (For Parents)
  103. Do Memory Problems Always Mean Alzheimers Disease?
  104. Manganese
  105. Study Shows that Disrupted Gut Bacteria May Contribute to the Spread of Breast Cancer
  106. She Faced Breast Cancer At 16 With Little Help From Doctors. Now She’s Speaking Out On Behalf Of Black Women
  107. What Do We Know About Healthy Aging?
  108. Participating in the Arts Creates Paths to Healthy Aging
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  136. Scientists revive cellular activity in brain of dead pigs: report – Fox News
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Tuesday, January 28, 2020
  1. 5-Ingredient Peanut Butter Chia Balls
  2. Healthy Vegetarian Meal Plan: Week of 01-25-2020
  3. Can neurogastronomy save the world?
  4. Healthy Tuna Noodle Casserole
  5. Healthy Vegetarian Meal Plan: 01-18-2020
  6. Pantry 2020 Basics
  7. Top 10 Tips for Cooking Dried Legumes
  8. What I Ate Wednesday + Day In the Life
  9. Brussels Sprout Kale Caesar Salad with Rosemary Croutons
  10. Healthy Vegetarian Meal Plan: Week of 01-11-2020
  11. Eat for your Dosha
  12. Keep it Moving
  13. No-Bake Chocolate Almond Butter Oatmeal Bars
  14. Apple Cider Vinegar for Digestion
  15. Healthy Vegetarian Meal Plan: Week of 01-04-2020
  16. Mediterranean Vegetable Pasta with Chickpeas
  17. Healthy Vegetarian Meal Plan: Week of 12-28-2019
  18. Get Well, Not High
  19. 21 Fabulously Festive Vegan Holiday Treats
  20. Healthy Vegetarian Meal Plan: Week of 12-21-2019
  21. Vegan Lasagna Soup
  22. Sweet Potato Rounds with Goat Cheese, Roasted Grapes, and Pecans
  23. Healthy Vegetarian Meal Plan: Week of 12-14-2019
  24. Vegan Peanut Butter Cup Cookies (Gluten-Free!)
  25. Kid-approved vegan eats
  26. Fudgy Avocado Walnut Brownies
  27. Healthy Vegetarian Meal Plan: Week of 12-07-2019
  28. Amazing Vegan Ginger Molasses Cookies
  29. 2019 Holiday Gift Guide For Her
  30. Herbal Inclusions for Dishes and Drinks
  31. 4 Diabetes Game Changers
  32. Healthy Vegetarian Meal Plan: Week of 11-30-2019
  33. Instant Pot Mashed Potatoes with Garlic and Cream Cheese
  34. Healthy Vegetarian Meal Plan: Week of 11-23-2019
  35. Wedding Planning: The Ring, Our Vendors, and More!
  36. Instant Pot Vegan Cream of Mushroom and Wild Rice Soup
  37. Healthy Vegetarian Meal Plan: Week of 11-16-2019
  38. Healthy Vegetarian Meal Plan: Week of 10-26-2019
  39. Healthy Vegetarian Meal Plan: Week of 11-02-2019
  40. Roasted Potato, Mushroom, and Lentil Kale Salad
  41. Healthy Vegetarian Meal Plan: Week of 11-09-2019
  42. Healthy Vegetarian Meal Plan
  43. Healthy Vegetarian Meal Plan
  44. What I Wednesday: FNCE in Philly!
  45. Potato, Mushroom, and Lentil Kale Salad
  46. Healthy Vegetarian Meal Plan
  47. Unearthing Evidence-Based Integrative Remedies to Stress
  48. Scribble Anxiety Away
  49. Best Hostess Gift Ever
  50. What I Ate Wednesday: Fiancé Edition!
  51. Pumpkin Walnut Burgers with Chipotle Yogurt Sauce
  52. Favorite Fluffy Whole Wheat Pancakes
  53. Healthy Vegetarian Meal Plan
  54. Vegan Chili Cornbread Casserole
  55. Healthy Vegetarian Meal Plan
  56. Orca Conservation
  57. Fall’s Functional Foods
  58. Healthy Vegetarian Meal Plan
  59. Healthy Pumpkin Cheesecake Dip
  60. Simple Swaps for Your Zero Waste Journey
  61. Lessons on Food and Farming in Monterey, California
  62. Healthy Vegetarian Meal Plan
  63. Quick and Easy-One Pan Veggie Red Curry
  64. Healthy Vegetarian Meal Plan: Week of 09-21-2019
  65. Here’s How to Live a more Colourful Life
  66. Cooking with CBD
  67. Eco-friendly Food Storage
  68. Bento Box Recipes
  69. How to Make Sushi Sandwich
  70. Healthy Vegan Buffalo Cauliflower Dip
  71. Healthy Vegetarian Meal Plan: Week of 09-14-2019
  72. 5 lunchbox ideas
  73. 17 Free and Easy Ways to Be a Self-Care Expert
  74. Fluffy Vegan Pumpkin Muffins
  75. Healthy Vegetarian Meal Plan: Week of 09-07-2019
  76. 33 Mouthwatering Healthy Vegetarian Recipes for Dinner Tonight
  77. What I Ate Wednesday
  78. The Best Apple Cider Vinegar Salad Dressing
  79. VOTE TODAY!
  80. Veggie Stir Fry with Peanut Sauce
  81. Twilight Time: Reading With Kids
  82. Keep your cool
  83. Tart Cherry Crumble Pie
  84. Healthy Vegetarian Meal Plan
  85. Healthy Vegetarian Meal Plan
  86. Your brain on… air pollution?
  87. Brain Boosters
  88. MCT oil Coconut’s healthful gift
  89. Hot right now
  90. Cupcakes for breakfast?
  91. Vegan Chocolate Zucchini Muffins
  92. What is CBD? A Guide to Health Benefits, Usage, and More!
  93. Healthy Vegetarian Meal Plan
  94. Hummus Toast – 4 Ways!
  95. What I Ate Wednesday
  96. Fluffy Vegan Blueberry Banana Muffins
  97. Advances in Colorectal Cancer Research
  98. Advances in Breast Cancer Research
  99. Cleft Palate With Cleft Lip
  100. What is CPR?
  101. What Is Dementia? Symptoms, Types, and Diagnosis
  102. Cushing Syndrome (For Parents)
  103. Do Memory Problems Always Mean Alzheimers Disease?
  104. Manganese
  105. Study Shows that Disrupted Gut Bacteria May Contribute to the Spread of Breast Cancer
  106. She Faced Breast Cancer At 16 With Little Help From Doctors. Now She’s Speaking Out On Behalf Of Black Women
  107. What Do We Know About Healthy Aging?
  108. Participating in the Arts Creates Paths to Healthy Aging
  109. Setting Goals to be More Active Slows Memory Decline in Older African Americans
  110. Study Shows Music Eases Pain and Other Symptoms for Patients Undergoing Breast Cancer Treatment
  111. 49-Year-Old Breast Cancer Patient Grateful She Didn’t Wait Until 50 for a Mammogram
  112. Teen’s Innovative “SMART Armour” Protects Breast Cancer Patients from Radiation
  113. New Drug Improves 3-Year Survival by 50% for Young Women with Stage IV Breast Cancer
  114. Young Mother’s Life Tragically Taken by Breast Cancer After She Refused Traditional Treatments
  115. NIH Study Tracks Exercise with Mobile Apps to Improve Heart Health
  116. Lion With Skin Cancer Has Received Radiation Therapy In Hospital
  117. 3rd Grader Writes Note for Teacher Battling Breast Cancer to Read Right Before Treatment
  118. Skin Care
  119. Have Back Pain? These Are the Basic Spinal Structures You Need to Know
  120. The Final Word on Whether Alcohol Actually Has Any Health Benefits
  121. New One-Time “Seed” Treatment for Breast Cancer Being Used in Philadelphia
  122. Julia Louis-Dreyfus Talks About The Side Effects of Chemotherapy
  123. Teacher on Leave for Breast Cancer Treatment Forced to Pay for Her Own Substitute
  124. 27-Year-Old Thought She Was Injured Falling Off A Horse, But Then She Learned She Had Breast Cancer
  125. Should Surgery And Radiation Be The Standard Treatment For DCIS? The COMET Study Is Finding Out
  126. Judge Rules That 3-Year-Old Child With Leukemia Must Get Chemo Against Parents’ Wishes
  127. This Charcoal Powder Drastically Whitens Teeth Without Any Chemicals
  128. These Black Cherry-Flavored Shots Help Accelerate Weight Loss
  129. Olivia Newton-John Talks About How She Stays Positive Amid Cancer Battle
  130. This Army Captain Mom Was Diagnosed with Breast Cancer When She Was Just 8 Weeks Pregnant
  131. High-Deductible Health Plans Linked to Delayed Diagnosis and Treatment of Breast Cancer
  132. Antibiotic shortages are putting Aboriginal kids at risk – The Conversation AU
  133. Cuddle beds bringing some physical comfort to end-of-life patients – ABC News
  134. People who skip breakfast are five times more likely to die after a heart attack – Daily Mail
  135. Yale researchers revive cells in dead pig brains – Yale Daily News
  136. Scientists revive cellular activity in brain of dead pigs: report – Fox News
  137. High-Deductible Health Policies Linked To Delayed Diagnosis And Treatment – NPR
  138. After Breast Cancer Diagnosis, Technology Professor Teaches Computers to Read Mammograms
  139. Fact or Fiction: What to Know About Smoking Cessation and Medications
  140. If Soap and Water Are Not Available, Hand Sanitizers May Be a Good Alternative
  141. Autism: Beware of Potentially Dangerous Therapies and Products
  142. One side of your brain might be giving you nightmares – Cosmos
  143. What Personality Tests Tell Us About Ourselves – NPR
  144. Having a resting heart rate of 75 beats per minute DOUBLES your risk of an early death – Daily Mail
  145. Wear protective goggles to play badminton
  146. Herbal drug kratom linked to almost 100 overdose deaths, CDC says – USA TODAY
  147. Ability to lift weights quickly can mean a longer life – EurekAlert
  148. Climate change is making allergy season worse – CNN
  149. 11 Unexpected Ways You Can Relieve Headaches – HuffPost
  150. New Jersey preschoolers have highest autism rates in the nation, researchers say
  151. Auburn gymnast who suffered severe injuries: My pain is not your entertainment
  152. A four-day work week could improve our health and cut carbon emissions
  153. Promising treatment for chronic fatigue syndrome fails large trial

YaleNew

In a stunning scientific breakthrough, Yale School of Medicine researchers restored brain activity in pigs that had died hours before. The finding could revolutionize the neuroscience field and how scientists conceive the boundaries between life and death.

By circulating a cocktail of cell-rejuvenating compounds throughout the pigs’ brains, the researchers prevented tissue decomposition and restored some cell function. If replicated, their technique could be used as a model for drug testing and has implications for how scientists understand brain plasticity after traumatic events such as strokes. 

But the researchers stressed that they did not restore consciousness to the brains. Although the group observed activity in individual cells, the brains lacked widespread, coordinated activity — a requirement for consciousness.

“We wanted to investigate what happens in the brain following global injury … and whether we could restore certain cellular and molecular functions in the whole, intact brain four hours after death,” co-first author Stefano Daniele GRD ’21 told the News. “We were successfully able to do so.” 

Daniele and co-first author Zvonimir Vrselja, research scientist in neuroscience, headed the study under the supervision of School of Medicine neuroscience professor Nenad Sestan.

It took Vrselja and Daniele several years of trial-and-error to refine their research protocol. In the end, each successful trial required a 10-hour sprint.

“We have an entire dance that we do,” Daniele said.

Typically, scientists will purchase test animals from speciality research companies. But Vrselja and Daniele took a different approach: Each iteration of the experiment began at a local food processing plant where the duo would wait for new specimen to become available.

“We did not want to kill any animals for this research,” Daniele explained. “ So we just simply made use of tissue that was going to be discarded.”

After securing the tissue, the two rushed back to the School of Medicine and removed the pig’s brain from its skull within four hours.

Vreslja and Daniele designed a system to pump and circulate their solution throughout the brain. For six hours, the contraption acted like an artificial circulatory system — pushing solution around the brain while simultaneously removing waste from the tissue.

“A lot of these components are readily available and no one really thought to put them together in a particular manner that could result in this type of study,” Daniele said.

Miraculously, following the treatment, the team was able to repeatedly show that cells in the brain could respond to stimuli. Drug treatment expanded the brain’s blood vessels. And individual neurons gave bursts of electrical activity.

By all accounts, a brain deprived of oxygen and other nutrients for four hours is considered dead. But the activity described in the study shows that brain cells are more robust and are able to survive longer than previously thought.

Still, for now, clinical definitions of brain death are intact.

“I don’t see anything in this report that should undermine confidence in brain death as a criterion of death,” Winston Chiong, a neurologist at the University of California at San Francisco told The Atlantic.

In 2016, when the team grew concerned that their experiment would cause neurons across the brain to fire together — the marker for consciousness —  they recruited Yale Interdisciplinary Center for Bioethics Director Stephen Latham, who became a co-author of the study.

In all studies involving human or animal subjects, federal law mandates that scientists must consult their institution’s ethics committees before starting research.Though the present study passed the bar, future studies may enter an ethical gray area.

“A disembodied brain that’s obtained from a pig that’s already dead is not an animal and it’s not a human subject,” Latham explained. “Nobody has jurisdiction to ask questions like ‘is this brain suffering? Can it suffer if it’s sitting alone in a vat unconnected to a body? Even if we see EEG [signal], does that indicate consciousness? Does it indicate pained consciousness in any way?’”

Following the landmark study’s publication, Sestan, the senior author, is calling for independent groups to replicate the findings.

Others in the medical community agree. Yale New Haven Hospital Chief of Neurology David Hafler, who was not involved in the study, told the News that the work needs replicating as the “natural process of science” drums onward.

“Until the work is replicated independently by another laboratory,” he said, “in my mind it doesn’t exist.”

Still, Hafler said that the results of the Yale study are “one of the most remarkable findings I’ve seen in my career.”

“I really congratulate them for just a game-changing paper,” Hafler told the News. “They should be proud to be from Yale.”

As of Wednesday night, Nature reported that 132 news outlets have picked up the study.

Marisa Peryer | marisa.peryer@yale.edu

Matt Kristoffersen | matthew.kristoffersen@yale.edu

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