The 7 Possible Hidden Causes of Your Thyroid Condition

The first thing we will talk about is Hashimotos Thyroiditis, This is a condition that is grossly underdiagnosed in this country, I have read estimates that show this condition effecting 1/2 of diagnosed hypothyroid conditions. According to the American Association of Clinical Endocrinologist, there are 27 million people in the US with this condition and more than 1/2 go undiagnosed. So if 1/2 go undiagnosed and 1/2 of the diagnosed have Hashimotos that’s a lot of sick people. I believe that those estimates are conservative and a much greater number of individuals are suffering with Hashimotos and don’t know it.

This is a crime because if you have Hashimotos you have an auto-immune condition not a thyroid condition so you are being treated for the wrong thing. let me say that again but differently, you do have thyroid problems but they are because your thyroid and thyroid enzymes are being attacked by your immune system. This needs to be handled completely differently than a traditional hypothyroid condition, and that’s why so many patients as well as doctors are frustrated with these cases.

The reason this autoimmune condition goes undiagnosed is:

• Your lab values may look normal this is where a practitioner of functional medicine is needed you need to look at functional levels as opposed to traditional lab values. Functional medicine is a cutting-edge approach to many chronic conditions. Functional medicine practitioners are like medical detectives looking to restore function not just treat your symptoms or diagnosis.

• If your doctor gives you thyroid medication and your thyroid stimulating hormone or TSH level returns to normal then your doctor feels the treatment was effective. So why do you still not feel well? Because you still have the autoimmune condition that caused the thyroid symptoms.

Running the appropriate testing can detect Hashimotos Thyroiditis. One such test is a thyroid antibody test to see if you are making antibodies to your thyroid.

The 1st hidden cause of your thyroid condition could be Hashimotos Thyroiditis

The second factor is estrogen. Excess estrogen will increase thyroid-binding globulin. thyroid binding globulin will prevent your inactive thyroid hormone from converting to the active form T3 when this happens your TSH might look normal your T4 might look normal and your doctor might tell you everything is fine but why do you still have symptoms? This is why it is so important to run a complete thyroid panel in this case the marker we are looking for is T3 uptake T3 uptake is inversely proportional to thyroid binding globulin, if we find that you low T3 uptake and have high thyroid binding globulin we need to look at estrogen and that is a whole other topic, but very important to the true resolution your thyroid problem.

The 2nd hidden cause of your thyroid condition could be Estrogen

Now remember I said hidden causes because many times the doctor you are seeing will not pick up on these causes, and there are two main reasons for this.

• Not running the proper test and in your doctor’s defense, this is all about training when you are trained in drug treatments and the experts you rely on for training are experts in drug training that’s why we’ve seen patients from the Mayo clinic that could not be helped until they found us. So not running the test from a functional perspective as opposed to a drug treatment perspective.

• The lab ranges they are comparing to are pathological ranges comparing you to sick people we look at functional ranges comparing you to healthy people. This is why your tests are normal but you know you are not normal you feel bad.

So back to cortisol. Cortisol is produced by the adrenal glands which sit right on top of the kidneys your adrenal glands are your stress glands and have a few functions but when you are exposed to long-term chronic stress the gland can get overwhelmed and the production of cortisol an indication of the function of the adrenal glands. One of the problems that can happen is excess cortisol this can result in the production of excess cytokines which can inhibit the pituitary from producing TSH thyroid stimulating hormone.

One of the tests that is often run for patients is called an adrenal stress index test to determine adrenal function. Now when you have adrenal dysfunction it can cause other problems so a nice side effect is not only do you get your thyroid better but other areas like your adrenal glands get better in the process.

The 3rd hidden cause of your thyroid condition could be Cortisol

Remember when I was talking about cortisol I talked about how the pituitary makes thyroid-stimulating hormone and that this is many times the only marker many doctors look at to determine how much medication to give you. One of the factors in the pituitary function is dopamine if dopamine production is off that can affect the TSH production of the pituitary, I think you are starting to get the picture that our bodies are made up of many interrelated functions that need to work together, it’s a team effort.

The big question is not if your TSH is low in the functional range or the traditional pathological range by why is it low and it could be dopamine. Let’s not forget that low dopamine can have symptoms like feelings of worthlessness or lack of focus your doctor may have you on other medications for those symptoms like antidepressants or Ritalin. The beauty of functional medicine is getting to the underlying cause of your thyroid problem we will likely correct other underlying problems all at the same time, which is a well-received and unique approach to thyroid conditions.

The 4th hidden cause of your thyroid condition could be Dopamine

Serotonin is a neurotransmitter and serotonin problems can cause symptoms like depression, and anxiety, it is interesting to note that there can be many causes of thyroid problems just like many causes of depression and sleep disorders so treating any of these by just using the symptom as a guide does not make sense you must be a detective and do many tests to find the underlying dysfunction.

With serotonin, we may do several things, one of which is a neurotransmitter assessment form and a comprehensive metabolic profile.
So if you are having symptoms of anxiety, depression, sleeping disorders, symptoms like PMS, and carbohydrate cravings it could be a serotonin problem.

The 5th hidden cause of your thyroid condition could be Serotonin

Prolactin is another hormone that can affect your pituitary if you remember earlier we talked about how the pituitary makes TSH or thyroid stimulating hormone. So if you have increased prolactin that will suppress the pituitary and suppress the production of TSH.

Remember that as long as your TSH is within the pathological reference range your doctor will not pick this up and that’s because he is not trained to look for functional ranges. I want to stress to all of you who love your doctor, he/she is doing the right thing for which they were trained. It’s all about training and that is why I have done extensive training in functional medicine and that is what enables me to help people who could not previously be helped.

So what is causing prolactin to be elevated? It could be low dopamine and progesterone. Anything that suppresses dopamine and progesterone function can increase prolactin and suppress TSH this is where the real doctoring comes in do the testing. If you’ve been told your labs are normal or even if you’re on thyroid hormone and it helps why do you need it?

So if prolactin is an issue you could have symptoms such as difficulty getting pregnant and leakage from the breast for men you may have decreased libido since prolactin suppresses testosterone the male sex hormone. And yes we have treated patients for thyroid and in the process they got pregnant once we restored proper prolactin levels, really cool, and again why I love doing this type of work.

The 6th hidden cause of your thyroid condition could be Prolactin

Cytokines are chemicals in the body that are produced in response to stress and or inflammation. If you have high levels of stress and by stress I mean emotional as well as chemical. Many people will say I’m not that stressed but they are and have no idea how chemically it’s wreaking havoc on their bodies. You can have toxic exposure to chemicals like some of my patients who work in nail salons or dry cleaning facilities, if you have a condition called leaky gut you can have food proteins stressing your immune system. The point is there are many hidden stressors in today’s world and if your cytokines are elevated it can suppress thyroid stimulating hormone, sometimes not enough to show up on the pathological lab ranges but enough to show up on the functional ranges.

To find out if cytokine elevation is contributing to your thyroid problem you need to do the testing. Professionals look at markers such as interleukin 6 and interleukin 10 to evaluate cytokine function. Once again this is not standard testing with your typical thyroid specialist, remember we are looking at function and trying to get to the underlying cause of your condition not just trying to figure out how much TSH to give you.

The 7th hidden cause of your thyroid condition could be Cytokines

The role of cytokines in thyroid conditions, particularly autoimmune thyroid diseases like Hashimoto’s thyroiditis and Graves’ disease, is an area of active research. Cytokines are small proteins involved in cell signaling and the regulation of immune responses. They play a crucial role in the body’s defense against infections and are also involved in various autoimmune processes.

In the context of thyroid disorders, cytokines can be associated with the inflammation of the thyroid gland. In autoimmune thyroiditis, such as Hashimoto’s disease, the immune system mistakenly targets the thyroid tissue, leading to inflammation. Cytokines are released during this inflammatory process, and they can contribute to the destruction of thyroid cells.

In Graves’ disease, another autoimmune thyroid condition, cytokines may also play a role. The immune system produces antibodies (specifically, thyroid-stimulating immunoglobulins) that bind to thyroid cells and stimulate the release of excess thyroid hormones. Cytokines may be involved in the signaling pathways that lead to the overproduction of these antibodies.

While the exact relationship between cytokines and thyroid disorders is still an active area of research, it’s clear that inflammation, driven by immune system activity and cytokine release, can be a contributing factor in thyroid conditions. Managing inflammation is often part of the treatment approach for these disorders, and researchers are exploring ways to modulate cytokine activity to potentially mitigate the autoimmune response and reduce thyroid gland damage. However, the understanding of these mechanisms may evolve as research progresses.